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SLC transporters are found in the small intestine, liver, kidney, and other tissues. They play important roles in the uptake of various drugs into cells, as well as endogenous nutrients, and thus may influence the absorption, distribution, metabolism, and excretion (ADME) properties of drugs. The interaction of a drug with SLC transporters as a substrate or inhibitor may result in drug interactions and hence impact its efficacy, toxicity, or both.
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