Novel Drug Modalities DMPK Enabling Platforms
WuXi AppTec DMPK has extensive experience and established pharmacokinetics evaluation systems for ADC, PDC, Oligo, Peptide, mRNA, Covalent Drugs, Proteolysis Targeting Chimera (PROTAC*) pharmacokinetic studies based on the in vivo and in vitro pharmacokinetic studies platform – to help drug developers quickly advance their drug development projects.
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Overview
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Novel Drug Modalities
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Related Resources
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Related Services
Novel Drug Modalities
Overview
Our dedicated R&D team has summarized pharmacokinetic research strategies and established comprehensive evaluation solution from in vitro to in vivo for different novel drug modalities. The team consists of experts in different fields covering in vitro and in vivo ADME, metabolite identification, QWBA and radiolabeled mass balance, and bioanalysis.
We have collaborated with pharmaceutical and biotech companies focusing on new drug modalities. We have successfully supported thousands of projects and conducted extensive testing on tens of thousands of drug molecules, including peptides, antibodies, oligonucleotides, PROTACs, ADCs, PDCs, mRNA, Covalent Drugs, and etc.
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Novel Drug Modalities
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PROTAC DMPK Services
Based on the pharmacokinetics evaluation systems for PROTAC molecules, WuXi AppTec DMPK has supported the screening of tens of thousands of PROTAC molecules and the IND applications of dozens of PROTAC molecules. In this process, we have formed a unique methodology for PROTAC pharmacokinetic studies - aimed at helping drug developers rapidly advance their PROTAC drug development projects.
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ADC (Antibody-Drug Conjugate) DMPK Services
Based on the ADC integrated platform, WuXi AppTec DMPK has supported more than 200 ADCs for screening and more than 20 ADCs for IND filing. Throughout this process, we have accumulated extensive experience and can propose a specific DMPK strategy for each ADC project, which can effectively shorten the ADC development cycle.
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Oligonucleotide Drugs DMPK Services
We have helped more than 70 global clients successfully screen and evaluate oligonucleotide pipelines, and have enabled dozens of oligonucleotide molecules’ IND applications, including ASO, siRNA, miRNA, and more. We not only have extensive experience in studying oligonucleotides but also have developed a specific methodology for the pharmacokinetic study of oligonucleotide drugs.
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Peptide-Drug Conjugate (PDC) DMPK Services
Based on the characteristics of PDCs, the development strategy and assay condition of PDCs are customized according to our experience. WuXi AppTec DMPK has successfully supported more than 20 clients on PDC projects, including some IND-enabling studies.
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Peptide Drugs DMPK Services
Based on the peptide integrated platform, WuXi AppTec DMPK has supported more than 140 global clients on peptide projects, including the screening of tens of thousands of peptide molecules and the IND applications of dozens of peptide molecules.
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mRNA-Based Vaccines and Therapeutics Drugs DMPK Services
To facilitate the research and development of mRNA-based vaccines and therapeutics, WuXi AppTec DMPK has established an integrated bioanalytical platform. This platform includes qPCR, branched DNA (bDNA), ligand binding assays (LBA), liquid chromatography-mass spectrometry (LC-MS), and flow cytometry, enabling quantitative and semi-quantitative analysis of mRNA.
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Covalent Drugs DMPK Services
The mechanism of covalent drugs is different from that of conventional small molecule drugs, which may bring corresponding challenges to the ADME studies, such as distribution and elimination studies. WuXi AppTec DMPK has established ADME platforms specially for covalent drugs. Up to now, WuXi AppTec DMPK has successfully supported nearly 100 covalent drug projects for clients and has successfully pushed many covalent drugs into clinical trials.
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Related Resources
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Decoding Peptide ADME Challenges: Integrated Radiolabeled Synthesis & ADME Platform - DMPK Frontiers
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In Vitro Metabolic Stability of Peptide Drugs Across Different Tissues
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Optimisation of an In Vitro Plated Monkey Hepatocyte Model and Comparative Metabolite Profiling of a GalNAc-Conjugated siRNA, siRNA01, in Monkey Liver Homogenate and Hepatocytes
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Biomimetic Chromatography Method to Estimate Human Plasma Protein Binding for Peptides
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Evaluation of Clearance Prediction Methods for Vepdegestrant (ARV-471) Using PBPK Modelling: Insights into PROTAC Clinical Pharmacokinetics
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Bioanalytical Strategy for Antibody-Drug Conjugates (ADCs) Based on Integrated Mass Spectrometry Bioanalysis Platform
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Novel Rat Intrathecal Catheterization Model for Direct Antisense Oligonucleotide (ASO) Drugs Delivery to the Central Nervous System
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Evaluating Oral Peptides' Gastrointestinal Absorption: Methods and Applications
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Advancing Novel Therapeutics with Innovative DMPK Strategies in Metabolism and Bioanalysis
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Radiolabeling Synthesis and ADME Profiling of GLP-1 Analogs: Strategies and Preclinical Insights
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An Efficient and Environmental Friendly Method for the Determination of Nucleoside Phosphate Compounds by Using LC-MS/MS
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Bioanalytical Strategy for Payload-Related Species of Antibody Drug Conjugates (ADCs) with LC-MS
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Antibody-Drug Conjugate (ADC) R&D Innovations and In Vitro ADME Research Considerations
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Solving the Peptide Puzzle: Strategies for Smarter Development
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An Integrated Radiolabeling and ADME Platform for Peptide Drugs
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mRNA Vaccines and Therapeutics: Advances in Modification, Delivery, Applications, and Analytical Strategies
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Optimization of Sample Pretreatment Methods for the Determination of an Oligonucleotide by Using LC-MS/MS
PostersJul 17, 2025Learn More -
Desorption Strategies in Peptide Formulation Preparation: Insights from In Vitro Adsorption (Non-Specific Binding) Assessment Experiments
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In Vitro Metabolic Stability Evaluation of Peptides
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Rapid Screening and Characterization of Payload-Related Catabolites Derived from ADCs in In Vitro Models by UPLC-UV-HRMS
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A Robust LC-MS/MS Method for the Detection of Covalent Drugs in Mouse Blood
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An Ultra High-Throughput Method for 13C6-Fructose-6-Phosphate in Cells Using Acoustic Ejection Mass Spectrometry (AEMS)
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A Novel Validated LC-MS/MS Method for the Determination of Survodutide in Mouse Liver
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Exploring T-Cell Engagers (TCEs): Mechanism, Challenges, and Pharmacokinetic Considerations
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In Vitro Metabolism Methods for Oligonucleotides
White PapersJun 20, 2025Learn More -
How to Analyze and Separate Oligonucleotides and Active Metabolites Using LC-MS/MS
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Sample Chapter: Proteolysis-Targeting Chimeras (PROTACs) from Drug Metabolism and Pharmacokinetics: Frontiers, Strategies, and Applications
PublicationsJun 06, 2025Learn More -
Intrathecal Administration Techniques for CNS Delivery in Non-Human Primates:Practical Tools for Oligonucleotide Drug Pharmacokinetics
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Advancing In Vitro Metabolic Models and Metabolite Identification for Oligonucleotide Therapeutics
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Unlocking Reliable In Vitro Metabolic Models for Oligonucleotide Therapeutics with the Latest Publication on DMD
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8 Commonly Used ADC Payloads and Their ADME and DDI Properties
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Discovery and Evaluation of Pyrazolo[3,4‑d]pyridazinone as a Potent and Orally Active Irreversible BTK Inhibitor
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Cyclic Peptides: FDA-Approved Drugs and Their Oral Bioavailability and Metabolic Stability Tactics
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Comparative Metabolism of a GalNAc-Conjugated siRNA, Inclisiran, Among Various In Vitro Systems and Correlations with In Vivo Metabolism in Rats
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2024 FDA-Approved Drug Highlights: Overview of Human Pharmacokinetics and DDI Profiles
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Detection and Characterization of In Vitro Payload-Containing Catabolites of Noncleavable Antibody-Drug Conjugates by High-Resolution Mass Spectrometry and Multiple Data Mining Tools
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Immunogenicity Testing: Definition, Guidelines, and Anti-Drug Antibody Detection
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An Efficient Bioanalytical Method for mRNA Drug in Mouse Blood and Tissue Samples
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Covalent Drugs DMPK Services
BrochuresApr 10, 2025Learn More -
Enhancing Permeability Through Exposed Polar Surface Area (EPSA) for Beyond Rule of Five (bRo5) Drug Candidates
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FAQs on Oligonucleotide DMPK Studies Stability, Distribution, Administration, and Bioanalysis
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Unlocking Precision in Peptide Metabolite Identification for Next-Gen Drug Development
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Marketed Bispecific Antibodies and Their Pharmacokinetic Characteristics
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Optimization of the LLOQ for Exatecan, a Widely-Used Antibody Drug Conjugate (ADC) Payload
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Bioanalytical Strategy for Quantitative Conjugated Payloads of Antibody-Drug Conjugates (ADCs) with Cleavable Linker
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Streamlining the Bioanalysis of Antibody-Drug Conjugates (ADCs): Simultaneous Determination of Total Antibodies and Conjugated Payloads
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Navigating Complexities in Oligonucleotides: DMPK Strategies and CNS-Targeting Solutions
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Antibody-Drug Conjugate (ADC) Preclinical PK/PD Study Strategies and Practices
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Development of a Rapid, High Throughput Quantitative Bioanalysis Method for Conjugated Payloads of Protease-Cleavable Antibody-Drug Conjugate (ADC) in Rat Serum Using Automated Immuno-Capture Based UPLC-MS/MS
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