OLIGO Series
Nucleic acid drugs have gained significant attention in recent years as a highly promising area of new drug development. This Oligo series provide valuable insights into the development of oligonucleotide drugs, including challenges and strategies in DMPK research, in vitro and in vivo pharmacokinetic study design, metabolite identification, bioanalytical strategies, and the application of multiple quantitative bioanalysis methods. It also explores the ADME characteristics of FDA-approved siRNA drugs and antisense oligonucleotides (ASOs).
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Novel Drug Modalities
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Therapeutic Areas
General Considerations and DMPK Strategies for Oligonucleotides
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Preclinical Drug Development Testing for Oligonucleotide Drugs
BrochuresMay 18,2023Learn More
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DMPK Challenges and Strategies for Developing Oligonucleotide Drugs
WebinarsMay 11,2023Learn More -
Overcoming Challenges when Developing Oligonucleotides for Ophthalmic Drugs
ArticlesAug 31,2023Learn More -
Oligos for Ocular Diseases: Overcoming the Challenges
BlogsApr 11,2024Learn More -
Webinar Q&A | DMPK Challenges and Strategies for Developing Oligonucleotide Drugs
BlogsJun 15,2023Learn More -
EMA/FDA Approved siRNA Drugs: ADME Study Overview and Data Interpretation
ArticlesAug 31,2023Learn More -
Absorption, Distribution, Metabolism, and Excretion Characteristics of FDA Approved Antisense Oligonucleotides (ASOs)
ArticlesAug 30,2023Learn More -
Delivery Systems of siRNA Drugs and Their Effects on the Pharmacokinetic Profile
ArticlesAug 30,2023Learn More -
Navigating Complexities in Oligonucleotides: DMPK Strategies and CNS-Targeting Solutions
WebinarsFeb 20,2025Learn More -
FAQs on Oligonucleotide DMPK Studies Stability, Distribution, Administration, and Bioanalysis
BlogsApr 03,2025Learn More
In Vitro ADME Studies for Oligonucleotide Therapeutics
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Plasma Protein Binding of Oligonucleotide Drugs: Implications, Methods and Strategies
ArticlesJun 27,2024Learn More -
Plasma Protein Binding of Nine Antisense Oligonucleotides by Ultrafiltration
PostersDec 19,2023Learn More -
Development of a Plasma Stability Assay of Oligonucleotides
PostersFeb 12,2024Learn More -
Plasma Protein Binding of Oligonucleotides Using Rapid Agarose Gel Electrophoretic Mobility Shift Assay
PostersMar 15,2024Learn More -
The Role and Challenges of Plasma Protein Binding in Oligonucleotide Drug Development
ArticlesNov 22,2023Learn More -
8 In Vitro Systems for Oligo Metabolism Study: Pros and Cons and Selection Suggestions
ArticlesAug 25,2024Learn More -
Methods and Strategies for In Vitro Metabolism Studies of Oligonucleotides
ArticlesJan 08,2025Learn More
Intrathecal Administration Technology for Oligonucleotide Drugs
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Intrathecal Antisense Oligonucleotides: PK and Strategy
ArticlesJul 04,2024Learn More -
4 Best Practices for Intrathecal Administration in CNS Drug Development
BlogsNov 12,2024Learn More -
Effective Intrathecal Injection/Catheterization in Rats for CNS Drugs: Challenges and Strategies
ArticlesJun 12,2025Learn More
Metabolite Identification (MetID) in Oligonucleotide Research
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In Vitro-In Vivo Metabolite Profiling and Identification of Oligonucleotide
PostersAug 30,2023Learn More -
Metabolite Profiling and Identification of Oligonucleotide in In Vitro Metabolic System
PostersOct 30,2023Learn More -
Effect of pH on Metabolite Profiling and Identification of GalNAc Conjugated siRNA in In Vitro Metabolic System
PostersJan 23,2024Learn More -
Oligonucleotide Drugs: Strategies for Metabolism and Metabolite Profiling and Identification
ArticlesSep 13,2023Learn More -
Comparative Metabolite Profiling and Identification of a GalNAc-Conjugated siRNA, siRNA01, in Plasma Prepared with Various Anticoagulants, Serum, and In Vivo Plasma Using LC-UV-HRMS
PostersOct 25,2024Learn More -
Comparative Metabolism of a GalNAc-Conjugated siRNA, Inclisiran, Among Various In Vitro Systems and Correlations with In Vivo Metabolism in Rats
PublicationsMay 08,2025Learn More
Bioanalysis for Oligonucleotide Drugs
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Quantitative Analysis of GalNAc-siRNA Conjugate Using Liquid Chromatograph Coupled with Triple Quadrupole Mass Spectrometry
PostersApr 28,2023Learn More -
The Advantage of LC-MS Method for Specific siRNA and It's Shortmer Quantitation to Support Mouse Liver Pharmacokinetics Study
PostersNov 30,2023Learn More -
A Comprehensive Bioanalytical Strategy of In Vivo Studies for RNAi Therapeutics in Early Discovery
PostersJan 31,2024Learn More -
Quantitative Analysis of GalNAc-siRNA Conjugates in Tissue Homogenate Using Two-Dimensional Liquid Chromatography Coupled with Tandem Mass Spectrometry
PostersFeb 22,2024Learn More -
Quantitative Analysis of a GalNAc-siRNA Conjugate and Its Metabolites Using Two-Dimensional Liquid Chromatography Coupled with Tandem Mass Spectrometry
PostersJul 04,2024Learn More -
Integrated Bioanalysis Strategies in Non-clinical Early In Vivo PK Studies of siRNAs
ArticlesSep 25,2023Learn More -
Rapid EMSA: A New Method of Testing PPB in Oligonucleotides
BlogsApr 30,2024Learn More -
Exploring Oligonucleotide Drugs: An Introduction and Overview of Pharmacokinetic and Bioanalytical Strategies
ArticlesNov 09,2023Learn More -
Application of Liquid Chromatography-Mass Spectrometry (LC-MS) in Oligonucleotides Quantitative Analysis
ArticlesOct 19,2023Learn More -
DMPK Quantitative Analysis of Oligonucleotides Using RT-qPCR
ArticlesSep 20,2023Learn More -
The Application of Ligand Binding Assay (LBA) in DMPK Quantitative Analysis of Oligonucleotides
ArticlesAug 31,2023Learn More -
Application of Liquid Chromatography-Fluorescence (LC-FL) Detection Methods for DMPK Quantitative Bioanalysis of Oligonucleotides
ArticlesAug 30,2023Learn More -
Validation and Comprehensive Bioanalytical Strategy of In Vivo Studies for RNAI Therapeutics in Early Discovery
PostersSep 13,2024Learn More
Radiolabeled ADME Studies for Oligonucleotide Pharmacokinetics
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