In Vitro Metabolism Methods for Oligonucleotides

White Papers
June 20,2025

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In vitro metabolic stability methods for oligonucleotides were established, evaluating critical factors: pH impact, subcellular matrices (liver S9/homogenate), plasma anticoagulants, and extraction techniques. Results show pH significantly influences metabolism, heparin plasma is optimal, and SPE/LLE yield comparable data. Validation used clinically relevant oligonucleotides to support in vivo predictability.

White Paper-In Vitro Metabolism Methods for Oligonucleotides

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