The Impact of Probe Substrate Selection on Reducing Off-Target Effects in Enzyme Phenotyping of Slow-metabolizing Drugs

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June 01,2026

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For the reaction phenotyping of slow-metabolizing compounds requiring high HLM concentrations or longer reaction times, amodiaquine is no longer suitable. Paclitaxel serves as a superior CYP2C8 probe substrate. Its use enables the assay to be performed under lower inhibitor concentrations, effectively minimizes off-target effects, and ensures the accurate identification of primary metabolic enzymes in drug metabolism studies.

The Impact of Probe Substrate Selection on Reducing Off-Target Effects in Enzyme Phenotyping of Slow-metabolizing Drugs

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