Optimizing DMPK Strategy for Peptide Drugs

Peptide drugs are known for their high specificity, strong target affinity, and low risk of off-target effects. However, compared to small molecule drugs, they suffer from low oral bioavailability, poor plasma stability, and short circulation time. Optimizing these DMPK (Drug Metabolism and Pharmacokinetics) properties of peptides is crucial for their development. This webinar will explore essential strategies for optimizing the DMPK profiles of peptides, including the selection of appropriate in vitro matrices, tailored sample processing techniques, and leveraging WuXi AppTec’s extensive experience and study platforms. Attendees will gain insights into the key factors that influence peptide drug development, from early screening to IND-enabling studies.

Learning objectives:

• Understand the specific DMPK properties and challenges associated with peptide drugs.

• Explore strategies to improve the stability, permeability, and bioavailability of peptide drugs.

• Understand the comprehensive DMPK approaches for successful peptide drug development, from screening to IND submission.